幸运大转盘

  1. Enheten
  2. Ansatte
  3. Johan Mattias Isaksson
Bilde av Isaksson, Johan Mattias
Bilde av Isaksson, Johan Mattias
Førsteamanuensis Institutt for farmasi johan.isaksson@uit.no +4777644842 41354726 Tromsø Her finner du meg

Johan Mattias Isaksson

Stillingsbeskrivelse

Responsible for the , which is a node in the , and a WP leader of the research project (DLN/RCN/幸运大转盘). I am also managing the analytical platform .

Teaching: FAR-2301, FAR-3301, KJE-3303/8303.

  • Sailesh Maharjan, Johan Mattias Isaksson, Krupov谩 Monika, Teppo R盲m盲, Kine 脴stnes Hansen, Jeanette Hammer Andersen m.fl.:
    Metabolomics-Guided Discovery of Bipolarolides H鈭扥, New Ophiobolin-Type Sesterterpenes with Antibacterial Activity from the Marine-Derived Fungus Uzbekistanica storfjordensis sp. nov.
    Journal of natural products 2025 /
  • Birta Ravdna Alexandersen Sarre, Olena Dobrovolska, Patrik Lundstr枚m, Diana Cornelia Turcu, Tatiana Agback, 脴yvind Halskau m.fl.:
    Structural dynamics of human deoxyuridine 5鈥-triphosphate nucleotidohydrolase (dUTPase)
    Scientific Reports 2024 /
  • Laura Schl眉ter, Kine 脴stnes Hansen, Johan Mattias Isaksson, Jeanette Hammer Andersen, Espen Holst Hansen, Jo虉rn Kalinowski m.fl.:
    Discovery of thiazostatin D/E using UPLC-HR-MS2-based metabolomics and 蟽-factor engineering of Actinoplanes sp. SE50/110
    Frontiers in Bioengineering and Biotechnology 2024 /
  • Maxim Brilkov, Martin Jakubec, Victoria Stenbakk, Terje Vasskog, Tone Kristoffersen, Jorunn Pauline Cavanagh m.fl.:
    Bacterial extracellular vesicles: towards realistic models for bacterial membranes in molecular interaction studies by surface plasmon resonance
    Frontiers in Molecular Biosciences 2023 /
  • Philip Ben Rainsford, Fredrik G. Rylandsholm, Martin Jakubec, Mitchell Silk, Eric Juskewitz, Johanna Ulrica Ericson m.fl.:
    Label-free measurement of antimicrobial peptide interactions with lipid vesicles and nanodiscs using microscale thermophoresis
    Scientific Reports 2023 /
  • Yannik Karl Heinz Schneider, Anton Liaimer, Johan Mattias Isaksson, Oda Sofie Bye Wilhelmsen, Jeanette Hammer Andersen, Kine 脴stnes Hansen m.fl.:
    Four new suomilides isolated from the cyanobacterium Nostoc sp. KVJ20 and proposal of their biosynthetic origin
    Frontiers in Microbiology 2023 /
  • Sara Ullsten-Wahlund, Guillaume Petit, Johan Mattias Isaksson, Ida Kristine 脴stnes Hansen, Yannik Karl Heinz Schneider, Marte Jenssen m.fl.:
    Identification of New Purpuroine Analogues from the Arctic Echinodermata Pteraster militaris That Inhibit FLT3-ITD+ AML Cell Lines
    International Journal of Molecular Sciences 2022 /
  • Philip Ben Rainsford, Birta R. Sarre, Margherita Falavigna, Bj酶rn Olav Brandsdal, G酶ril Eide Flaten, Martin Jakubec m.fl.:
    WIND-PVPA: Water/Ion NMR Detected PVPA to assess lipid barrier integrity in vitro through quantification of passive water- and ion transport
    Biochimica et Biophysica Acta - Biomembranes 2022 /
  • Eric Juskewitz, Ekaterina Mischenko, Vishesh Kumar Dubey, Marte Jenssen, Martin Jakubec, Philip Rainsford m.fl.:
    Lulworthinone: In Vitro Mode of Action Investigation of an Antibacterial Dimeric Naphthopyrone Isolated from a Marine Fungus
    Marine Drugs 2022 /
  • Fazlin Pheiffer, Yannik Karl Heinz Schneider, Espen Holst Hansen, Jeanette Hammer Andersen, Johan Mattias Isaksson, Tobias Busche m.fl.:
    Bioassay-Guided Fractionation Leads to the Detection of Cholic Acid Generated by the Rare Thalassomonas sp.
    Marine Drugs 2022 /
  • Venke Kristoffersen, Marte Jenssen, Heba Raid Jawad, Johan Isaksson, Espen Hansen, Teppo R盲m盲 m.fl.:
    Two Novel Lyso-Ornithine Lipids Isolated from an Arctic Marine Lacinutrix sp. Bacterium
    Molecules 2021 /
  • Marianne Hagensen Paulsen, Magnus Engqvist, Dominik Ausbacher, Trude Anderssen, Manuel K- Langer, Tor Haug m.fl.:
    Amphipathic Barbiturates as Mimics of Antimicrobial Peptides and the Marine Natural Products Eusynstyelamides with Activity against Multi-resistant Clinical Isolates
    Journal of Medicinal Chemistry 2021 /
  • Marte Jenssen, Venke Kristoffersen, Kumar Motiram-Corral, Johan Isaksson, Teppo R盲m盲, Jeanette Hammer Andersen m.fl.:
    Chlovalicin B, a Chlorinated Sesquiterpene Isolated from the Marine Mushroom Digitatispora marina
    Molecules 2021 /
  • Marte Jenssen, Philip Rainsford, Eric Juskewitz, Jeanette Hammer Andersen, Espen Hansen, Johan Isaksson m.fl.:
    Lulworthinone, a New Dimeric Naphthopyrone From a Marine Fungus in the Family Lulworthiaceae With Antibacterial Activity Against Clinical Methicillin-Resistant Staphylococcus aureus Isolates
    Frontiers in Microbiology 2021 /
  • Ida Kristine 脴stnes Hansen, Johan Isaksson, Aaron G. Poth, Kine 脴stnes Hansen, Aaron John Christian Andersen, C茅line Sarah Marine Richard m.fl.:
    Isolation and characterization of antimicrobial peptides with unusual disulfide connectivity from the colonial ascidian Synoicum turgens
    Marine Drugs 2020 /
  • Olena Dobrovolska, Maxim Brilkov, No毛lly Madeleine, 脴yvind 脴degaard-Fougner, 脴yvind Str酶mland, Stephen R. Martin m.fl.:
    The Arabidopsis (ASHH2) CW domain binds monomethylated K4 of the histone H3 tail through conformational selection
    The FEBS Journal 2020 /
  • Worku Dinku, Johan Isaksson, Fredrik G. Rylandsholm, Petr Bou艡, Eva Brichtova, Sang Un Choi m.fl.:
    Anti-proliferative activity of a novel tricyclic triterpenoid acid from Commiphora africana resin against four human cancer cell lines
    Applied Biological Chemistry 2020 /
  • Yngve Guttormsen, Magnus John Espeland Fairhurst, Sunil Kumar Pandey, Johan Isaksson, Bengt Erik Haug, Annette Bayer :
    Total synthesis of phorbazole B
    Molecules 21. oktober 2020 / PROSJEKT /
  • Yannik Karl-Heinz Schneider, Marte Jenssen, Johan Isaksson, Kine 脴stnes Hansen, Jeanette Hammer Andersen, Espen Hansen :
    Bioactivity of Serratiochelin A, a Siderophore Isolated from a Co-Culture of Serratia sp. and Shewanella sp.
    Microorganisms 14. juli 2020 /
  • Ikenna E. Ndukwe, Yu-hong Lam, Sunil Kumar Pandey, Bengt Erik Haug, Annette Bayer, Edward C. Sherer m.fl.:
    Unequivocal structure confirmation of a breitfussin analog by anisotropic NMR measurements
    Chemical Science 21. september 2020 /
  • Aitor Moreno, Kine 脴stnes Hansen, Johan Isaksson :
    CSSF-CLIP-HSQMBC: measurement of heteronuclear coupling constants in severely crowded spectral regions
    RSC Advances 2019 /
  • Raja Priyanka Mary Michael Siranjeevi, Espen Hansen, Johan Isaksson, Jeanette hammer Andersen, Kine 脴stnes Hansen :
    Dendrobeaniamine A, a new alkaloid from the Arctic marine bryozoan Dendrobeania murrayana
    Natural Product Research 2019 /
  • Kine 脴stnes Hansen, Jeanette hammer Andersen, Annette Bayer, Sunil Kumar Pandey, Marianne Lorentzen, K氓re Bredeli J酶rgensen m.fl.:
    Kinase chemodiversity from the Arctic: the breitfussins
    Journal of Medicinal Chemistry 2019 /
  • Yannik Karl-Heinz Schneider, Kine 脴stnes Hansen, Johan Isaksson, Sara Maria Ullsten-Wahlund, Espen Hansen, Jeanette Hammer Andersen :
    Anti-Bacterial Effect and Cytotoxicity Assessment of Lipid 430 Isolated from Algibacter sp.
    Molecules 2019 /
  • Venke Kristoffersen, Teppo R盲m盲, Johan Isaksson, Jeanette hammer Andersen, William H. Gerwick, Espen Hansen :
    Characterization of Rhamnolipids Produced by an Arctic Marine Bacterium from the Pseudomonas 铿倁orescence Group
    Marine Drugs 2018 /
  • Kine 脴stnes Hanssen, Johan Isaksson, Eirin Glomsaker, Jeanette hammer Andersen, Espen Hansen :
    Ponasterone A and F, Ecdysteroids from the Arctic Bryozoan Alcyonidium gelatinosum
    Molecules 2018 /
  • Sundus Ahkter, Bjarte Aarmo Lund, Aya Ismael, Manuel Langer, Johan Isaksson, Tony Christopeit m.fl.:
    A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design
    European Journal of Medicinal Chemistry 2018 /
  • Bjarte Aarmo Lund, Ane Molden Thomassen, Birgit Helene Berg Nesheim, Trine Josefine Olsen Carlsen, Johan Isaksson, Tony Christopeit m.fl.:
    The biological assembly of OXA鈥48 reveals a dimer interface with high charge complementarity and very high affinity
    The FEBS Journal 2018
  • Jostein Grip, Rolf Einar Engstad, Ingrid Skj忙veland, Natasa Skalko-Basnet, Johan Isaksson, Purusotam Basnet m.fl.:
    Beta-glucan-loaded nanofiber dressing improves wound healing in diabetic mice
    European Journal of Pharmaceutical Sciences 2018 /
  • Raja Priyanka Mary Michael Siranjeevi, Kine 脴stnes Hanssen, Johan Isaksson, Jeanette hammer Andersen, Espen Hansen :
    A Novel Brominated Alkaloid Securidine A, Isolated from the Marine Bryozoan Securiflustra securifrons
    Molecules 2017 /
  • Kine 脴stnes Hansen, Johan Isaksson, Annette Bayer, Jostein a Johansen, Jeanette hammer Andersen, Espen Hansen :
    Securamine Derivatives from the Arctic Bryozoan Securiflustra securifrons
    Journal of natural products 2017
  • Marc Stierhof, Kine Hansen, Mukesh Sharma, Klaus Feussner, Karolina Subko, Fernando Fern脿ndez Diaz-Rullo m.fl.:
    New cytotoxic callipeltins from the Solomon Island marine sponge Asteropus sp.
    Tetrahedron 2016
  • Johan Mattias Isaksson :
    Structural Dynamics Characterization of human dUTPase - a target in cancer
    2023
  • Maxim Brilkov, Jorunn Pauline Cavanagh, Johan Mattias Isaksson, Johanna E. Sollid, G酶ril Eide Flaten :
    BACTERIALLY PRODUCED IN VITRO MEMBRANE MODEL SYSTEMS FROM RESISTANT- AND NON-RESISTANT CLINICAL ISOLATES
    2023
  • Philip Ben Rainsford, Maxim Brilkov, Finn Lillelund Aachmann, G酶ril Eide Flaten, Johan Mattias Isaksson :
    NMR tube inserts for time-resolved spatial NMR
    2023
  • Yannik Karl Heinz Schneider, Anton Liaimer, Johan Mattias Isaksson, Oda Sofie Bye Wilhelmsen, Jeanette Hammer Andersen, Kine 脴stnes Hansen m.fl.:
    Corrigendum: Four new suomilides isolated from the cyanobacterium Nostoc sp. KVJ20 and proposal of their biosynthetic origin (Frontiers in Microbiology, (2023), 14, (1130018), 10.3389/fmicb.2023.1130018)
    Frontiers in Microbiology 2023
  • Maxim Brilkov, Jorunn Pauline Cavanagh, Johan Mattias Isaksson, Johanna U Ericson :
    Outer-membrane vesicles as a bacterial membrane model to study interaction of antimicrobial peptides
    2023
  • Monika Krupova, Karolina Di Remigio Eik氓s, Johan Mattias Isaksson, Kenneth Ruud :
    Vibrational Circular Dichroism of Antimicrobial Peptides: What is Their Structure in Solution and in Membranes?
    2022
  • Philip Ben Rainsford, Johan Mattias Isaksson :
    Expanding the toolbox for the study of antimicrobial peptides
    幸运大转盘 Norges arktiske universitet 2022
  • Maxim Bril'kov, Jorunn Pauline Cavanagh, Johan Mattias Isaksson, Johanna U Ericson, G酶ril Eide Flaten :
    Bacterially produced in vitro mambrane model systems from resistant- and non-resistant clinical isolates
    2022
  • Johan Mattias Isaksson :
    CSSF-CLIP-HSQMBC
    2020
  • Johan Isaksson :
    CSSF-CLIP-HSQMBC: Measurement of heteronuclear coupling constants in severely crowded spectral regions
    2020
  • Priyanka Michael, Espen Hansen, Johan Isaksson, Jeanette hammer Andersen, Kine 脴stnes Hansen :
    Dendrobeaniamine A, a New Alkaloid from the Arctic Marine bryozoan Dendrobeania murrayana
    2019
  • Johan Isaksson :
    CSSF-CLIP-HSQMBC: Measurement of heteronuclear coupling constants in severely crowded spectral regions
    2019
  • Aitor Moreno, Kine 脴. Hanssen, Johan Isaksson :
    CSSF-CLIP-HSQMBC: Measurement of heteronuclear coupling constants in severely crowded spectral regions
    2019
  • Kine 脴. Hanssen, Jeanette hammer Andersen, Bert Klebl, Jan Eickhoff, Johan Isaksson, Espen Hansen :
    Novel kinase inhibitors from the Arctic marine hydrozoan Thuiaria breitfussi
    2019
  • Johan Isaksson, Birta Ravdna Sarre :
    鈥淒ynamics characterization of dUTPase, a new target in cancer therapy鈥
    2018
  • Tor Haug, Runar Gjerp Solstad, Chun Li, Johan Isaksson, Jostein a Johansen, Johan Svenson m.fl.:
    Halogenated antimicrobial peptides from the red sea urchin, Echinus esculentus.
    2017
  • Marc Boomgaren, Birta Ravdna Sarre, Tor Arne Heim Andberg, Bj酶rn Olav Brandsdal, Johan Isaksson, J酶rn H Hansen :
    Synthesis and exploration of a novel molecular scaffold for dUTPase inhibition: Aiming for new anticancer agents
    2017
  • Bjarte Aarmo Lund, Sundus Akhter, Yngve Guttormsen, Tony Christopeit, Johan Isaksson, Annette Bayer m.fl.:
    Structure-guided drug design for the antibiotic resistance enzyme OXA-48
    2016

    • CV

    2011- Research and NMR site management, Tromsø University, Norway
    2009

    PostDoc scientist for Prof. John Sigurd Svendsen in Organic chemistry (NMR), Tromsø University, Norway
    2005

    NMR Research scientist (pharmaceutic industry), Medivir AB, Sweden
    2005

    Ph.D. in Bioorganic chemistry (NMR), Uppsala University, Sweden
    1998 M.Sc. in Biomedical chemistry, Kalmar University, Sweden