Morten Bøhmer Strøm
Stillingsbeskrivelse
Morten B. Strøm er Prodekan forskning og innovasjon ved Det helsevitenskapelige fakultet. Han er professor i legemiddelkjemi ved Institutt for farmasi, Forskningsgruppe i naturstoff- og legemiddelkjemi. Forskningen hans omhandler utvikling av peptider og peptid etterligninger (peptidomimetika) med aktivitet mot resistente bakterier og med aktivitet mot kreftceller. Sammen med andre forskningsgrupper ved 幸运大转盘 studerer vi hvordan disse molekylene kan utvikles til å bli fremtidige legemidler og legemiddelformuleringer. Dette har gitt viktig erfaring innen innovasjon, patentering og kommersialisering.
Professor ved Forskningsgruppe i naturstoff- og legemiddelkjemi.
Vitenskapelige arbeidsomr氓der
Dominik Ausbacher,
Lindsey A. Miller,
Darla M. Goeres,
Philip S. Stewart,
Morten B酶hmer Str酶m,
Adyary Fallarero
:
伪,伪-disubstituted 尾-amino amides eliminate Staphylococcus aureus biofilms by membrane disruption and biomass removal
Biofilm 2023 /
Susannah von Hofsten,
Manuel K Langer,
Katja Korelin,
Synn酶ve Norvoll Magnussen,
Dominik Ausbacher,
Trude Anderssen
m.fl.:
Amphipathic barbiturates as marine product mimics with cytolytic and immunogenic effects on head and neck squamous cell carcinoma cell lines
Frontiers in Pharmacology 30. mars 2023 /
Lisa Myrseth Hemmingsen,
Barbara Giordani,
Marianne Hagensen Paulsen,
Zeljka Vanic,
G酶ril Eide Flaten,
Beatrice Vitali
m.fl.:
Tailored anti-biofilm activity 鈥 Liposomal delivery for mimic of small antimicrobial peptide
Biomaterials Advances 2023 /
Manuel K Langer,
Ataur Rahman,
Hymonti Dey,
Trude Anderssen,
Hans-Matti Blencke,
Tor Haug
m.fl.:
Investigation of tetrasubstituted heterocycles reveals hydantoins as a promising scaffold for development of novel antimicrobials with membranolytic properties
European Journal of Medicinal Chemistry 2023 /
Alexandra Sofia Antunes de Sousa,
Vegard Bor酶y,
Agnethe Hansen B忙verud,
Kjersti Julin,
Annette Bayer,
Morten B. Str酶m
m.fl.:
Polymyxin B stabilized DNA micelles for sustained antibacterial and antibiofilm activity against P. aeruginosa
Journal of materials chemistry. B 2023 /
Susannah von Hofsten,
Marianne Hagensen Paulsen,
Synn酶ve Magnussen,
Dominik Ausbacher,
Mathias Kranz,
Annette Bayer
m.fl.:
The marine natural product mimic MPM-1 is cytolytic and induces DAMP release from human cancer cell lines
Scientific Reports 2022 /
Hymonti Dey,
Danijela Simonovic,
Ingrid Sofie Norberg-Schulz Hagen,
Terje Vasskog,
Elizabeth G. Aarag Fredheim,
Hans-Matti Blencke
m.fl.:
Synthesis and Antimicrobial Activity of Short Analogues of the Marine Antimicrobial Peptide Turgencin A: Effects of SAR Optimizations, Cys-Cys Cyclization and Lipopeptide Modifications
International Journal of Molecular Sciences 2022 /
Manuel K Langer,
Ataur Rahman,
Hymonti Dey,
Trude Anderssen,
Francesco Zilioli,
Tor Haug
m.fl.:
A concise SAR-analysis of antimicrobial cationic amphipathic barbiturates for an improved activity-toxicity profile
European Journal of Medicinal Chemistry 2022 / / /
Marianne Hagensen Paulsen,
Magnus Engqvist,
Dominik Ausbacher,
Trude Anderssen,
Manuel K- Langer,
Tor Haug
m.fl.:
Amphipathic Barbiturates as Mimics of Antimicrobial Peptides and the Marine Natural Products Eusynstyelamides with Activity against Multi-resistant Clinical Isolates
Journal of Medicinal Chemistry 2021 /
Ida Kristine 脴stnes Hansen,
Tomas L枚vdahl,
Danijela Simonovic,
Kine 脴stnes Hansen,
Aaron John Christian Andersen,
hege Devold
m.fl.:
Antimicrobial activity of small synthetic peptides based on the marine peptide turgencin A: Prediction of antimicrobial peptide sequences in a natural peptide and strategy for optimization of potency
International Journal of Molecular Sciences 2020 /
Marianne Hagensen Paulsen,
Dominik Ausbacher,
Annette Bayer,
Magnus Engqvist,
Terkel Hansen,
Tor Haug
m.fl.:
Antimicrobial activity of amphipathic 伪,伪-disubstituted 尾-amino amide derivatives against ESBL鈥揅ARBA producing multi-resistant bacteria; effect of halogenation, lipophilicity and
cationic character
European Journal of Medicinal Chemistry 2019 /
Runar Gjerp Solstad,
Cecilie Johansen,
Klara Stensv氓g,
Morten B. Str酶m,
Tor Haug
:
Structure鈥恆ctivity relationship studies of shortened analogues of the antimicrobial peptide EeCentrocin 1 from the sea urchin Echinus esculentus
Journal of Peptide Science 2019 /
Marianne Hagensen Paulsen,
Eskil Andre Karlsen,
Dominik Ausbacher,
Trude Anderssen,
Annette Bayer,
Philipp Ochtrop
m.fl.:
An amphipathic cyclic tetrapeptide scaffold containing halogenated 尾2,2-amino acids with activity
against multi-resistant bacteria
Journal of Peptide Science 2018
Elizaveta Igumnova,
Ekaterina Mishchenko,
Tor Haug,
Hans-Matti Blencke,
Johanna U Ericson Sollid,
Elizabeth Aarag
m.fl.:
Amphipathic sulfonamidobenzamides mimicking small antimicrobial marine natural products; investigation of antibacterial and anti-biofilm activity against antibiotic resistant clinical isolates.
Bioorganic & Medicinal Chemistry 2018
Vilde Flaget Hesle,
Camtu Cathrine Tran,
Morten B. Str酶m,
Odd Reidar Gautun
:
Synthetic studies towards amphipathic pyrazino-pyrimidine-dione scaffolds for antimicrobial testing
2024
Hymonti Dey,
Hans-Matti Blencke,
Morten B. Str酶m,
Elizabeth G. Aarag Fredheim,
Tor Haug
:
Antimicrobial activities and mechanisms of action of peptide analogues of marine origin
2024
Alexandra Sofia Antunes De Sousa,
Mona Susan Johannessen,
Annette Bayer,
Morten B酶hmer Str酶m,
Natasa Skalko Basnet,
Sybil Akua Okyerewa Obuobi
:
Study of the penetration ability of DNA nanoparticles in biofilms
2024
Ataur Rahman,
Manuel Karl Langer,
Bartosz Michno,
Hans-Matti Blencke,
Tor Haug,
Johanna Ulrica Ericson
m.fl.:
Novel synthetic cationic antimicrobial peptides and their potential in combating antibiotic resistance
2024
Ataur Rahman,
Klara Stensv氓g,
Hans-Matti Blencke,
Annette Bayer,
Ekaterina Mischenko,
de Freitas Almeida Gabriel Magno
m.fl.:
Bioactivity profiling and mode of action studies of antibacterial and antibiofilm agents of marine origin
幸运大转盘 Norges arktiske universitet 2024
Hymonti Dey,
Danijela Simonovic,
Celine Sarah Marine Richard,
Ingrid Sofie Norberg-Schultz Hagen,
Natascha Johansen,
Frode Jacobsen 脴yen
m.fl.:
Combining outer membrane active synthetic antimicrobial peptides with vancomycin or erythromycin increases antibacterial and antibiofilm activities
2024
Ataur Rahman,
Manuel Karl Langer,
Bartosz Michno,
Hans-Matti Blencke,
Tor Haug,
Morten B. Str酶m
m.fl.:
Novel synthetic cationic antimicrobial peptides and their potential as antibiofilm agents
2024
Julie Sofie Kleppe Str酶mberg,
Tor Haug,
Morten B. Str酶m,
Terkel Hansen,
Terje Vasskog,
Johannes Kristensen
m.fl.:
Structure Elucidation of the Disulfide Connectivity in Marine Antimicrobial Disulfide Rich Peptides
2023
Lisa Myrseth Hemmingsen,
Barbara Giordani,
Marianne Hagensen Paulsen,
Zeljka Vanic,
G酶ril Eide Flaten,
Beatrice Vitali
m.fl.:
Liposomes in topical delivery of mimic of small antimicrobial peptide - Improving the anti-biofilm effect
2023
Manuel K Langer,
Ataur Rahman,
Hymonti Dey,
Trude Anderssen,
Hans-Matti Blencke,
Tor Haug
m.fl.:
Tetrasubstituted hydantoins: Novel membranolytic antimicrobials
2023
Christoffer 脜gnes,
Ataur Rahman,
hege Devold,
Klara Stensv氓g,
Morten B. Str酶m,
Tor Haug
:
Antibacterial and antibiofilm activity in Arctic and sub-Arctic marine benthic invertebrates
2023
Christoffer 脜gnes,
Ataur Rahman,
Hege Devold,
Klara Stensv氓g,
Morten B酶hmer Str酶m,
Tor Haug
:
Antibacterial and antibiofilm compounds in six marine invertebrates from Arctic and sub-Arctic Oceans
2023
Ataur Rahman,
Manuel K Langer,
Hans-Matti Blencke,
Tor Haug,
Johanna U Ericson,
Morten B. Str酶m
m.fl.:
Development of novel antimicrobial peptides: two classes with improved antimicrobial and antibiofilm activity
2023 PROSJEKT
Alexandra Sofia Antunes de Sousa,
Kjersti Julin,
Annette Bayer,
Morten B酶hmer Str酶m,
Mona Johannessen,
Natasa Skalko-Basnet
m.fl.:
Drug-loaded DNA nanoparticles against bioflms
2023
Hymonti Dey,
Danijela Simonovic,
Ingrid Sofie Norberg-Schulz Hagen,
Terje Vasskog,
Elizabeth G. Aarag Fredheim,
Hans-Matti Blencke
m.fl.:
Antimicrobial activity and mode of action study of short cyclic analogues of the marine antimicrobial peptide Turgencin A
2023
Ataur Rahman,
Manuel K Langer,
Bartosz Michno,
Hans-Matti Blencke,
Tor Haug,
Johanna U Ericson
m.fl.:
In vivo toxicity and activity of newly developed novel analogues of short-cationic antimicrobial peptides as novel antibacterial agents
2023
Ataur Rahman,
Manuel K Langer,
Bartosz Michno,
Hans-Matti Blencke,
Tor Haug,
Johanna U Ericson
m.fl.:
In vivo toxicity and activity of newly developed novel analogues of short-cationic antimicrobial peptides as novel antibacterial agents
2023
Hymonti Dey,
Danijela Simonovic,
Ingrid Sofie Norberg-Schulz Hagen,
Terje Vasskog,
Elizabeth G. Aarag Fredheim,
Hans-Matti Blencke
m.fl.:
Antimicrobial Activity and Mode of Action Study of Short
Analogues of The Marine Antimicrobial Peptide Turgencin A
2022
Danijela Simonovic,
Hymonti Dey,
Natascha Johansen,
Trude Anderssen,
Terje Vasskog,
Elizabeth G. Aarag Fredheim
m.fl.:
Investigation of the antimicrobial activity and proteolytic stability
of the short analogues of the marine peptide EeCentrocin 1
2022
Lisa Myrseth Hemmingsen,
G酶ril Eide Flaten,
Morten B. Str酶m,
Natasa Skalko-Basnet
:
Membrane-active antimicrobials 鈥 in synergy with nature 鈥 the role of chitosan
2022
Kjersti Julin,
Annette Bayer,
Morten B酶hmer Str酶m,
Mona Johannessen,
Natasa Skalko-Basnet,
Sybil Akua Okyerewa Obuobi
:
DNA Nanocarriers for improved biofilm penetration
2022
Susannah von Hofsten,
Marianne Hagensen Paulsen,
Manuel K Langer,
Synn酶ve Norvoll Magnussen,
Dominik Ausbacher,
Annette Bayer
m.fl.:
A Compound Inspired by Arctic Marine Animals Kills Cancer Cells in vitro and in vivo
2022
Nima Alinejad Chatli,
Morten B. Str酶m,
Danijela Simonovic,
Tor Haug
:
Synthesis of linear and cyclic proline-rich analogues of the marine, antimicrobial peptides Hyasin 1 and Arasin 1
幸运大转盘 Norges arktiske universitet 2022
Ingrid Norberg-Schulz Hagen,
Danijela Simonovic,
Tor Haug,
Morten B. Str酶m
:
Synthesis of short lipopeptide analogues of the marine, antimicrobial peptide Turgencin A
幸运大转盘 Norges arktiske universitet 2021
Natascha Johansen,
Danijela Simonovic,
Tor Haug,
Morten B. Str酶m
:
Synthesis of analogues of the antimicrobial lead peptide P6 developed from the marine peptide EeCentrocin 1
幸运大转盘 Norges arktiske universitet 2021
Hymonti Dey,
Danijela Simonovic,
Ingrid Sofie Norberg-Schulz Hagen,
Terje Vasskog,
Elizabeth G. Aarag Fredheim,
Hans-Matti Blencke
m.fl.:
Antimicrobial activity and mode of action study of short analogues of the marine antimicrobial peptide Turgencin A
2021
Danijela Simonovic,
Hymonti Dey,
Natascha Johansen,
Trude Anderssen,
Terje Vasskog,
Elizabeth G. Aarag Fredheim
m.fl.:
Investigation of the antimicrobial activity and proteolytic stability of the short analogues of the marine peptide EeCentrocin 1
2021
Runar Gjerp Solstad,
Morten B. Str酶m,
Cecilie Johansen,
Klara Stensv氓g,
Tor Haug
:
Antimicrobial peptides
2020
Ataur Rahman,
Manuel Karl Langer,
Hymonti Dey,
Jonathan Hira,
Ekaterina Mishchenko,
Annette Bayer
m.fl.:
Novel antimicrobial and biofilm-inhibitors from marine resources
2020
Susannah von Hofsten,
Synn酶ve Norvoll Magnussen,
Dominik Ausbacher,
Marianne Hagensen Paulsen,
Annette Bayer,
Morten B. Str酶m
m.fl.:
The Marine Natural Product Mimic MHP88 Shows Anticancer Activity and has the Potential to Cause Immunogenic Cell Death
2020
Lisa Myrseth Hemmingsen,
Ann Kristin Pettersen,
Morten B. Str酶m,
Natasa Skalko-Basnet
:
Nano-antimicrobials in biofilm eradication - Optimization of stability and toxicity profile
2020
Klara Stensv氓g,
Jonathan Hira,
Ekaterina Mishchenko,
Hans-Matti Blencke,
Morten B. Str酶m,
Bjarne Landfald
m.fl.:
Marine antimicrobial peptides 鈥 an inspiration for new compounds to fight bacteria
2019
Runar Gjerp Solstad,
Morten B. Str酶m,
Cecilie Johansen,
Klara Stensv氓g,
Tor Haug
:
Antimicrobial peptides
2018
Runar Gjerp Solstad,
Morten B. Str酶m,
Cecilie Johansen,
Klara Stensv氓g,
Tor Haug
:
Antimicrobial peptides
2018
Runar Gjerp Solstad,
Morten B. Str酶m,
Cecilie Johansen,
Klara Stensv氓g,
Tor Haug
:
Antimicrobial peptides
2018
Manuel K Langer,
Marianne Hagensen Paulsen,
Morten B. Str酶m,
Annette Bayer
:
Amphipathic Hydantoins 鈥 potential new antibiotics
Mimicing the marine antimicrobials eusynstyelamides
2018
Publikasjoner utenom Cristin
Publikasjonsliste
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Patenter
Forskningsinteresser
Professor, prodekan forskning og innovasjon
STILLINGSBESKRIVELSE
Morten B. Strøm er Prodekan forskning og innovasjon ved Det helsevitenskapelige fakultet. Han er professor i legemiddelkjemi ved Institutt for farmasi, Forskningsgruppe i naturstoff- og legemiddelkjemi. Forskningen hans omhandler utvikling av peptider og peptid etterligninger (peptidomimetika) med aktivitet mot resistente bakterier og med aktivitet mot kreftceller. Sammen med andre forskningsgrupper ved 幸运大转盘 studerer vi hvordan disse molekylene kan utvikles til å bli fremtidige legemidler og legemiddelformuleringer. Dette har gitt viktig erfaring innen innovasjon, patentering og kommersialisering.
Professor ved Forskningsgruppe i naturstoff- og legemiddelkjemi.
FORSKNINGSINTERESSER
1) Design, synthesis and development of antimicrobial and anticancer peptides and peptidomimetics as lead-compounds for drug-development and investigation of pharmacophore models.
2) Design and synthesis of peptidomimetics and bioactive scaffolds for optimization of potency and pharmacokinetic properties.
3) Isolation and structural elucidation of marine bioactive compounds from Arctic and sub-Arctic marine invertebrates and synthesis of marine natural product mimics (marine bio-prospecting).
ORCID: .
Veiledning av PhD studenter
- 2000 – 2004: Biveileder for PhD Morten K. Moe - Tittel på PhD avhandling: ESI low-energy tandem MS characterisation of lipids modified by a novel derivatisation method. Finansiert av Norges Forskningsråd.
- 2007 – 2010: Biveileder for PhD Margey Tadesse - Tittel på PhD avhandling: Antimicrobial natural products from Arctic and sub-Arctic marine invertebrates. Finansiert av 幸运大转盘.
- 2007 – 2011: Hovedveileder for PhD Terkel Hansen (cand. pharm.) - Tittel på PhD avhandling: Antimicrobial and anticancer beta-peptidomimetics – synthesis and biological evaluation of a new class of small and highly potent compounds. Finansiert av 幸运大转盘.
- 2008 – 2012: Hovedveileder for PhD Dominik A. Ausbacher (cand. pharm.) - Tittel på PhD avhandling: Biological activity of β2,2-amino acid derivatives derived from antimicrobial peptides - Investigations of antimicrobial and anticancer activity and the mechanisms of action. Finansiert av 幸运大转盘.
- 2008 – 2013: Hovedveileder for PhD Veronika Tørfoss (cand. pharm.) - Tittel på avhandling: Short anticancer peptides containing a lipophilic β2,2-amino acid - Synthesis and biological evaluation of linear and cyclic hepta-, hexa-, penta-, and tetrapeptides. Finansiert av Norges Forskningsråd (KOSK-II programmet).
- 2011 – 2015: Biveileder for PhD Elisabeth Klungerbo Olsen (cand. pharm.) - Tittel på avhandling: Bioprospecting of Arctic marine organisms. Finansiert av MabCent – SFI.
- 2011 – 2015: Hovedveileder for Elizaveta Mikhailovna Igumnova - Arbeidstittel: Chemical synthesis, isolation, and structural characterization of marine bioactive hit compounds. Finansiert av MabCent – SFI.
- 2011 – 2016: Biveileder for PhD Runar Gjerp Solstad - Tittel på avhandling: Discovery of antimicrobial peptides in two invertebrates, the sea anemone Urticina eques and the sea urchin chinus esculentus - Isolation, characterization and structure-activity relationship studies. Finansiert av 幸运大转盘.
- 2012 – 2017: Hovedveileder for PhD Marianne Hagensen Paulsen - Tittel på avhandling: Synthetic mimics of antimicrobial peptides. Synthesis and biological studies of novel synthetic mimics of antimicrobial peptides. Finansiert av Norges Forskningsråd og 幸运大转盘 - "Fellesløftet".
- 2014 – 2017: Biveileder for PhD Thomas Aleksander Bakka (NTNU - Trondheim) - Tittel på avhandling: Synthesis and antimicrobial evaluation of small molecule amphiphiles derived from amphiphilic antimicrobial natural products. Finansiert av NTNU.
- 2018 – pågående prosjekt: Biveileder for Christoffer Ågnes Sivertsen (Fakultet for biovitenskap, fiskeri og økonomi - BFE, NFH 幸运大转盘) - Arbeidstittel: Antibacterial and antibiofilm compounds in Arctic and sub-Arctic invertebrates. Finansiert av 幸运大转盘 - Norges arktiske universitet - "Tematiske satsninger" - AntifoMar.
- 2018 – 2022: Biveileder for PhD Manuel Karl Langer (Institutt for kjemi - IKJ, 幸运大转盘) - Tittel på avhandling: Marine natural product inspired synthesis towards new antimicrobial and antifouling agents. Finansiert av 幸运大转盘 - Norges arktiske universitet - "Tematiske satsninger" - AntifoMar.
- 2019 – 2023: Biveileder for PhD Susannah von Hofsten (Institutt for medisinsk biologi - IMB, 幸运大转盘) - Tittel på avhandling: Anticancer activity of amphipathic barbiturates. Finansiert av 幸运大转盘 - Norges arktiske universitet.
- 2018 – 2023: Hovedveileder for PhD Danijela Simonovic (Institutt for farmasi - IFA, 幸运大转盘) - Tittel på avhandling: Synthesis and structure-activity relationship studies of marine-derived antimicrobial peptides and small cyclic peptidomimetics. Finansiert av 幸运大转盘 - Norges arktiske universitet - "Tematiske satsninger" - LEADScAMR.
- 2019 – 2024: Biveileder for PhD Ataur Rahman (Fakultet for biovitenskap, fiskeri og økonomi - BFE, NFH 幸运大转盘) - Tittel på avhandling: Bioactivity profiling and mode of action studies of antibacterial and antibiofilm agents of marine origin. Finansiert av 幸运大转盘 - Norges arktiske universitet - "Tematiske satsninger" - AntifoMar.
- 2019 – 2024: Biveileder for PhD Hymonti Dey (Fakultet for biovitenskap, fiskeri og økonomi - BFE, NFH 幸运大转盘) - Tittel på avhandling: Antimicrobial activities and mechanisms of action of peptide analogues of marine origin. Finansiert av 幸运大转盘 - Norges arktiske universitet - "Tematiske satsninger" - LEADScAMR
Veiledning av masterstudenter
Jeg har siden 2003 vært veileder for 31 mastergradsstudenter i farmasi / legemiddelkjemi / organisk kjemi.
Undervisning
FAR-2301: Legemiddelkjemi og naturstoffkjemi
FAR-3301: Avansert farmasøytisk kjemi
Medlem i forskningsgruppe
CV
Akademisk bakgrunn:
1994: Bachelor / Cand. Mag. i kjemi (幸运大转盘).
1996: Master / Cand. Scient. i organisk kjemi (幸运大转盘). Tittel på mastergradsoppgave / hovedfagsoppgave: “Syntese av substratanaloger for collagenase ved peptidsyntese i løsning".
1996: Forsker ved Universitetssykehuset i Nord-Norge (UNN).
1997: PhD / doktorgradsstudent i organisk kjemi (幸运大转盘).
2001: Philosophiae Doctor (PhD) i organisk kjemi. Tittel på avhandling: “Lactoferricin as a model system for preparing highly active antimicrobial peptides”.
2001: Post doc.
2002 – 2012: Førsteamanuensis ved Institutt for farmasi (幸运大转盘).
2006: Universitetspedagogisk seminar (UPS) gjennomført.
2012: Professor ved Institutt for farmasi (幸运大转盘).
2022 - : Prodekan forskning og innovasjon, Det helsevitenskapelige fakultet (幸运大转盘).
Undervisning
FAR-2301: Legemiddelkjemi og naturstoffkjemi
FAR-3301: Avansert farmasøytisk kjemi