幸运大转盘

Bilde av Heiland, Ines
Foto: Art of moments
Bilde av Heiland, Ines
Coordinator Institutt for arktisk og marin biologi ines.heiland@uit.no +4777646889 Tromsø Her finner du meg

Ines Heiland


Stillingsbeskrivelse

Prof. for Molecular Biology and Bioinformatics


  • Roland Sauter, Suraj Sharma, Ines Heiland :
    Accounting for NAD Concentrations in Genome-Scale Metabolic Models Captures Important Metabolic Alterations in NAD-Depleted Systems
    Biomolecules 2024 /
  • Lena Elise H酶yland, Magali R Van Linden, Marc Niere, 脴yvind Str酶mland, Suraj Sharma, J枚rn Lukas Franz Dietze m.fl.:
    Subcellular NAD+ pools are interconnected and buffered by mitochondrial NAD+
    Nature Metabolism 2024 /
  • Anna-Sophia Egger, Eva Rauch, Suraj Sharma, Tobias Kipura, Madlen Hotze, Thomas Mair m.fl.:
    Linking metabolism and histone acetylation dynamics by integrated metabolic flux analysis of Acetyl-CoA and histone acetylation sites
    Molecular Metabolism 2024 /
  • Suraj Sharma, Yin-Chen Hsieh, J酶rn Dietze, Mathias Bockwoldt, 脴yvind Str酶mland, Mathias Ziegler m.fl.:
    Early Evolutionary Selection of NAD Biosynthesis Pathway in Bacteria
    Metabolites 2022 /
  • Soumya R Mohapatra, Ahmed Sadik, Suraj Sharma, Gernot Poschet, Hagen M Gegner, Tobias V Lanz m.fl.:
    Hypoxia Routes Tryptophan Homeostasis Towards Increased Tryptamine Production
    Frontiers in Immunology 2021 / /
  • Mirja Tamara Prentzell, Ulrike Rehbein, Marti Cadena Sandoval, Ann-Sofie De Meulemeester, Ralf Baumeister, Laura Broh茅e m.fl.:
    G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling
    Cell 2021 / PROSJEKT / / /
  • J酶rn Dietze, Alienke van Pijkeren, Anna-Sophia Egger, Mathias Ziegler, Marcel Kwiatkowski, Ines Heiland :
    Natural isotope correction improves analysis of protein modification dynamics
    Analytical and Bioanalytical Chemistry 2021
  • Mathias Ziegler, Magnus Monn猫, Andrey Nikiforov, Gennaro Agrimi, Ines Heiland, Ferdinando Palmieri :
    Welcome to the Family: Identification of the NAD+ Transporter of Animal Mitochondria as Member of the Solute Carrier Family SLC25
    Biomolecules 2021 /
  • Verena Panitz, Sa拧a Kon膷arevi膰, Ahmed Sadik, Dennis Friedel, Tobias Bausbacher, Saskia Trump m.fl.:
    Tryptophan metabolism is inversely regulated in the tumor and blood of patients with glioblastoma
    Theranostics 2021 /
  • Alienke Van Pijkeren, J酶rn Dietze, Alejandro S谩nchez Brotons, Anna-Sophia Egger, Tim Lijster, Andrei Barcaru m.fl.:
    Combined metabolic and chemical (CoMetChem) labeling using stable isotopes - A strategy to reveal site-specific histone acetylation and deacetylation rates by LC-MS
    Analytical Chemistry 2021
  • Mathias Bockwoldt, Ines Heiland, Karsten Fischer :
    The evolution of the plastid phosphate translocator family
    Planta 2019
  • 脴yvind Str酶mland, Marc Niere, Andrey Nikiforov, Magali R Van Linden, Ines Heiland, Mathias Ziegler :
    Keeping the balance in NAD metabolism
    Biochemical Society Transactions 2019 /
  • Mathias Bockwoldt, Dorothee Houry, Marc Niere, Toni I. Gossmann, Ines Reinartz, Alexander Schug m.fl.:
    Identification of evolutionary and kinetic drivers of NAD-dependent signaling
    Proceedings of the National Academy of Sciences of the United States of America (PNAS) 24. juli 2019 /
  • Alexander Martin Heberle, Patricia Razquin Navas, Miriam Langelaar-Makkinje, Katharina Kasack, Ahmed Sadik, Erik Faessler m.fl.:
    The PI3K and MAPK/p38 pathways control stress granule assembly in a hierarchical manner
    Life Science Alliance (LSA) 2019 /
  • Fabrizio Clarelli, Jingyi Liang, Antal Martinecz, Ines Heiland, Pia Abel zur Wiesch :
    Multi-scale modeling of drug binding kinetics to predict drug efficacy
    Cellular and Molecular Life Sciences (CMLS) 2019 /
  • Soumya R. Mohapatra, Ahmed Sadik, Lars-Oliver Tykocinski, J酶rn Dietze, Gernot Poschet, Ines Heiland m.fl.:
    Hypoxia Inducible Factor 1伪 Inhibits the Expression of Immunosuppressive Tryptophan-2,3-Dioxygenase in Glioblastoma
    Frontiers in Immunology 2019 /
  • Arina Afanasyeva, Mathias Bockwoldt, Christopher Cooney, Ines Heiland, Toni Ingolf Gossmann :
    Human long intrinsically disordered protein regions are frequent targets of positive selection
    Genome Research 2018 /
  • Isabell Adam, Dyah L. Dewi, Joram Mooiweer, Ahmed Sadik, Soumya R. Mohapatra, Bianca Berdel m.fl.:
    Upregulation of tryptophanyl-tRNA synthethase adapts human cancer cells to nutritional stress caused by tryptophan degradation
    Oncoimmunology 2018 /
  • Sascha Sch盲uble, Anne-Kristin Stavrum, Mathias Bockwoldt, P氓l Puntervoll, Ines Heiland :
    SBMLmod: a Python-based web application and web service for efficient data integration and model simulation
    BMC Bioinformatics 2017 / /
  • Dyah L Dewi, Soumya R Mohapatra, Saioa Blanco Caba帽es, Isabell Adam, Luis F Somarribas Patterson, Bianca Berdel m.fl.:
    Suppression of indoleamine-2, 3-dioxygenase 1 expression by promoter hypermethylation in ER-positive breast cancer
    Oncoimmunology 2017
  • Christiane A. Opitz, Ines Heiland :
    Dynamics of NAD-metabolism: everything but constant
    Biochemical Society Transactions 2015
  • Ines Heiland, K Thedieck :
    Nutrigenomics: Toward a cross-disciplinary understanding of nutrient-driven networks in health and disease: What can we learn from the study of cross-talk in complex protein kinase and metabolic networks?
    Aktuelle Ern茫hrungsmedizin 2015
  • Walter Wencke, Bernd Ketelsen, Gaquerel Emmanuel, Ian T. Baldwin, Kim Sang-Gyu, Ines Heiland :
    Improving the accuracy of expression data analysis in time course experiments using resampling
    BMC Bioinformatics 2014 / /
  • Anne-Kristin Stavrum, Ines Heiland, Stefan Schuster, P氓l Puntervoll, Mathias Ziegler :
    Model of tryptophan metabolism, readily scalable using tissue-specific gene expression data
    Journal of Biological Chemistry 2013 /
  • Kathrin Schmeisser, Johannes Mannsfeld, Doreen Kuhlow, Sandra Weimer, Steffen Priebe, Ines Heiland m.fl.:
    Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide
    Nature Chemical Biology 2013
  • Sascha Sch盲uble, Anne-Kristin Stavrum, P氓l Puntervoll, Stefan Schuster, Ines Heiland :
    Effect of substrate competition in kinetic models of metabolic networks
    FEBS Letters 2013 /
  • Ines Heiland, Christoph Kaleta :
    Stoffwechselanalyse: Neue Wege im Labyrinth entdecken
    Laborwelt 2012
  • Sunniva Katharina Thode, Ines Heiland :
    Energisentrene i cellene holder oss friske
    23. februar 2025
  • Ines Heiland :
    Kinetic regulation of NAD homeostasis
    2022
  • Anze Zupanic, Hans Christopher Bernstein, Ines Heiland :
    Systems biology 鈥 Current status and challenges
    Cellular and Molecular Biology 2020 /
  • Mathias Bockwoldt, Ines Heiland, Toni Ingolf Gossmann, Thomas Rattei :
    Sequence-Based Analysis of Eukaryotic Protein Evolution
    幸运大转盘 Norges arktiske universitet 2018
  • Toni Ingolf Gossmann, Arina Afanasyeva, Mathias Bockwoldt, Ines Heiland, Cooney Chris :
    Human intrinsically long disordered protein regions are frequent targets of positive selection
    2017
  • Roland Sauter, Ines Heiland :
    Arctic Marine Bioplastics
    2017
  • Mathias Bockwoldt, Ines Heiland, Gossmann Toni, Mathias Ziegler :
    Phylogenetic and simulation-based analysis of NAD metabolism
    2016
  • Roland Sauter, Ines Heiland :
    Metabolic Modeling of Marine Biomass Conversion
    2016
  • Ines Heiland, Mathias Bockwoldt, P氓l Puntervoll, Sascha Sch盲uble, Anne-Kristin Stavrum :
    Tissue specific models of Trp- and NAD-metabolism 鈥 insights into metabolic crosstalk.
    2016
  • Mathias Bockwoldt, Ines Heiland :
    Phylogenetic Analysis of NAD biosynthesis and consumption
    2016
  • Ines Heiland, Mathias Bockwoldt, Anne-Kristin Stavrum, P氓l Puntervoll, Mathias Ziegler :
    Tissue specific models of Tryptohan-metabolism 鈥 insights into metabolic crosstalk
    2016
  • Mathias Bockwoldt, Anne-Kristin Stavrum, Toni I. Gossmann, Mathias Ziegler, Ines Heiland :
    Dynamics of NAD-metabolism - everything but constant
    2015
  • Carolyn Elliss, Thomas Rattei, Ines Heiland :
    50 Years of FEBS麓 Education Training Awards
    FEBS News 2015
  • Mathias Bockwoldt, Ines Heiland :
    Phylogenetic Analysis of NAD biosynthesis and consumption
    2015
  • Mathias Bockwoldt, Ines Heiland :
    Use of resampling to improve accuracy of data analysis in time course experiments
    2015
  • Ines Heiland :
    Chemo Informatik: Was hat Tryptophan mit Krebs und Parkinson zu tun?
    Chemie in unserer Zeit 2014
  • Wencke Walter, Emmanuel Gaquerel, Ian T. Baldwin, Sang-Gyu Kim, Ines Heiland :
    Improving the analysis of high throughput time course data using modelling based approaches
    2014
  • Ines Heiland, Susanne Brandes, Anne-Kristin Stavrum, Christian Bodenstein, Mathias Ziegler :
    NAD-metabolism and the circadian clock -- Unraveling contradictions
    2014
  • Anne-Kristin Stavrum, Ines Heiland, Stefan Schuster, P氓l Puntervoll, Mathias Ziegler :
    Predicting pathological metabolic changes using a kinetic model of tryptophan metabolism
    2014
  • Ines Heiland, Susanne Brandes, Anne-Kristin Stavrum, Christian Bodenstein, Mathias Ziegler :
    NAD-metabolism and the circadian clock
    2013
  • Ines Heiland :
    Metabolic modelling: From networks to dynamics and back
    2013


  • Publikasjoner utenom Cristin

     


    Forskningsinteresser

    Mathematical simulations are an important tool in physics and engineering, but its application to biology and medicine is still in its infancy. However, as our knowledge of the molecular basis of biological processes is progressing, mathematical modelling is increasingly used to understand the complexity of living organisms.

    We use existing biochemical data to built dynamic models of metabolisms and ageing. The resulting models can be used to understand the basis of diseases and guide the development of drugs. We work in close collaboration with experimental groups, which is advantageous, as model building is always an iterative process of simulation and experimental verification of model hypothesis. It furthermore guides the developement of our models and usually defines the aim of the model.

    Undervisning

    Current teaching activities

    BIO-2018 Anvendt molekylærbiologi og bioinformatikk 

    BIO-3027 Scientific Programming with Pyhthon for Life Sciences

    BIO-3010/8011 Modelling in Systems Biology I -Metabolic pathway modelling

    Chair of the board of the National Research School for Bioinformatics, Biostatistics and Systems Biology ()

    Past teaching activities:

    Basis pedagogisk kompetanse 2016 -




    CV

    Positions

     

    Sept/2015 - Prof. for molecular biology and  bioinformatics at the

     

    Dec/2012 - Sept/2015 Assoc. Prof. for molceular bioinformatics at the

    2008 - 2012
    Postdoctoral researcher and junior group leader at the
    Project: Modelling and simulation of circadiane rhythms and dynamic metabolic processes

    2005 - 2006
    Postdoctoral reseracher at the FSU Jena Department of General Botany
    Project: Data evaluation of large scale proteome projects of C. reinhardtii

    2004 - 2005
    Postdoctoral researcher at the Ruhr University Bochum
    Project: Characterisation of the Pex3p-Complexes of Saccharomyces cerevisiae

     

    PhD-Thesis

    2003 - 2004
    2001 - 2002

    I have done my in the group of Prof. Ralf Erdmann. The title of my work was: "Investigating peroxisomal membrane biogenesis". I have defended my PhD thesis at the 19th of November in 2004 at the FU Berlin.

     

    Internships

    04/2011 - 05/2011 Computational Biology Unit, Uni Reserach, Bergen, Norway

    03/2004 - 04/2004 Biological school of sciences, C. Stirling Group, Manchester University, England

    06/1999 - 07/1999 Department of Organic Chemistry, S. Oscarsons Group, Arhenius Laboratories, Stockholm University, Sweden

     

    Undergraduate Studies in Biochemistry

    1995 - 1997
    1997 - 2000