As a scientist with a keen interest in the field of liver biology, my research primarily focuses on understanding the role of liver sinusoidal endothelial cells (LSECs) in the development and progression of non-alcoholic fatty liver disease to steatohepatitis (NASH). NASH is a chronic liver disease that is rapidly becoming a major health concern worldwide, and its prevalence is rapidly increasing. It is characterized by a buildup of fat in the liver, leading to inflammation, liver damage, and eventually, liver failure.
My research aims to understand the underlying mechanisms of LSEC dysfunction in NASH and identify potential therapeutic targets to prevent or treat this disease.
I am using various cutting-edge techniques, including advanced imaging, such as super-resolution optical microscopy, transcriptomics, proteomics, and functional assays, to investigate the complex interplay between LSECs, other liver cells, and environmental factors that contribute to the development of NASH.
Keywords for research interests:
- LSECs in NAFLD and NASH
- LSECs metabolic reprograming in health and disease
- LSECs role in coagulopathy
- Coregulation of metabolism and transcription in LSECs
- Advanced microscopy including optical nanoscopy for metabolic studies
