ÐÒÔË´óתÅÌ

Disputasen strømmes og et opptak vil være tilgjengelig i et døgn.
The defense will be streamed, and a recording of the disputation will be available for 24 hours.

Prøveforelesning over oppgitt emne starter kl. 10.15 / The trial lecture starts at 10.15
Tittel/Title:  "Incorporating Nanotechnology into Advanced Wound Healing Therapies.”


Disputasen starter kl. 12.15 / The defense starts at 12.15



Populærvitenskapelig sammendrag av avhandlingen/ Summary of the thesis:

Non-healing wounds, chronic wounds, are at risk of infection and challenging to treat, wherefore novel wound dressings are needed.
To improve treatment options, we aimed at the development of a novel wound dressing that works as a tailored transport system of an incorporated antibiotic (chloramphenicol) and is composed of natural substances to use nature to aid the healing process.
We chose beta-glucan from yeast, chitosan from shrimps, and pectin from citrus peels, which have antimicrobial, wound healing and high swelling abilities, respectively. For a tailored antibiotic transport, we added chloramphenicol in small fatty vesicles, liposomes.
Using electrospinning, a technique that fabricates dressings with a unique nanosized fibrous structure (nanofibers), we manufactured dressings with the chosen ingredients in various complexities.
The nanofibers had a high ability to take up simulated wound fluid and maintained the activity of chloramphenicol, showing potential as wound dressings.

Veiledere/ Supervisors:
Hovedveileder/Main supervisor:
 Førsteamanuensis Ann Mari Holsæter, Institutt for farmasi, Det helsevitenskapelige fakultet, ÐÒÔË´óתÅÌ Norges arktiske universitet.

Biveiledere/supervisors:
Professor Nataša Škalko-Basnet, Institutt for farmasi, Det helsevitenskapelige fakultet, ÐÒÔË´óתÅÌ Norges arktiske universitet.
CSO Rolf Engstad, Biotec BetaGlucans AS.
Professor Mona Johannessen, Institutt for medisinsk biologi, Det helsevitenskapelige fakultet, ÐÒÔË´óתÅÌ Norges arktiske universitet.

Bedømmelseskomité/Defensecomitee:

Professor Romána Zelkó, Semmelweis University – 1. opponent.
Ph.d.  Cătălina Bogdan, Iuliu HaÈ›ieganu University of Medicine and Pharmacy – 2. opponent.
Førsteamanuensis Kristian Svendsen, Institutt for farmasi, Det helsevitenskapelige fakultet, ÐÒÔË´óתÅÌ Norges arktiske universitet – leder av komité.

Disputasleder/ Leader of defense: 
Førsteamanuensis Kjell H. Halvorsen, Institutt for farmasi, Det helsevitenskapelige fakultet, ÐÒÔË´óתÅÌ Norges arktiske universitet.